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This is a critical and exciting period in the development of antisense oligonucleotides (ONs) as therapeutic agents. Recently, there has been substantial progress in developing newer, more effective chemistries for ONs (1). Ongoing clinical trials using antisense have yielded promising results, particularly in the context of cancer therapy (2). Finally, important new roles for antisense as a tool...
Despite their simple conceptual basis, antisense strategies turned out more difficult to implement than initially anticipated. Overwhelming enthusiasm in academic laboratories and in the biotechnology industry in the early 1990s has been followed by a wave of skepticism about the real potential of nucleic acidsbased drugs. An antisense oligonucleotide (ON)-based drug has been approved for the treatment...
Cancer gene therapy relies on nucleic acid carriers. Because of their diversity, viruses fulfill most requirements for gene delivery in clinical situations. However, parallel evolution of viruses and their hosts has made foreign protein particles, as well as infected cells, effective targets for the immune system. Although the latter consequence can be turned into therapeutic benefit, the former excludes...
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